In the Season 5 premiere, Will and Natalie face the aftermath of a horrific car incident and are left to battle for their lives. An investigation is launched following the suspicious death of the elder Cornelius Rhodes, Dr. Rhodes’ father. Maggie receives life-changing news. Dr. Charles cuts his honeymoon short to tend to a young patient he suspects might have schizophrenia.

Season 05, Episode 02 – “We’re Lost in the Dark”
Dr. Choi and Dr. Charles face difficult decisions as a dying man tries to preserve his future life with a controversial scientific method. Dr. Marcel and April clash over how to handle a mysterious patient and Will questions Natalie’s capabilities. Sharon assigns a nurse to shadow Maggie, much to her dismay.

Season 05, Episode 03 – “In the Valley of The Shadows ”
Dr. Choi and Dr. Marcel don’t see eye-to-eye over the treatment of a patient’s chronic pain and rumors start to circulate about Maggie. Dr. Manning works to help a young boy, but her treatment suggestions are challenged by the parents who believe in only using holistic remedies.

Season 05, Episode 04 – “Infection, Part 2”
Part 2 of a three-show crossover event: An entire apartment complex is forced into quarantine when cases of the deadly virus turns into an epidemic. P.D. chases a lead that could point to a case of bioterrorism and Will gets dangerously close to the suspect.

Season 05, Episode 05 – “Got A Friend in Me”
Dr. Choi and Dr. Marcel don’t see eye-to-eye over the treatment of a patient’s chronic pain and rumors start to circulate about Maggie. Dr. Manning works to help a young boy, but her treatment suggestions are challenged by the parents who believe in only using holistic remedies.

Season 05, Episode 06 – “It’s All in the Family”
Dr. Manning’s actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

Season 05, Episode 07 – “Who Knows What Tomorrow Brings”
Dr. Charles and Dr. Halstead sink their teeth into a bloodthirsty case; Dr. Marcel and Maggie throw a traditional crawfish boil for the staff and a new relationship blossoms.

Season 05, Episode 08 – “Too Close to the Sun ”
Maggie gets unsettling news about a new friend and breaks protocol to support him. One of the doctors from the Med family is rushed into emergency surgery after a violent assault. A social media influencer lets his users vote on medical advice, forcing Dr. Charles to make a decision.

Season 05, Episode 09 – “I CAN’T IMAGINE THE FUTURE”
April receives unfortunate news that makes her question her future with Ethan. Dr. Charles and Maggie see tough times on the horizon. Natalie’s memory from the accident starts to return.

Season 05, Episode 10 – “GUESS IT DOESN’T MATTER ANYMORE”
Dr. Halstead’s world is thrown into turmoil when a former patient resurfaces. April has a secret she considers confessing to Ethan. Dr. Charles tries to maintain his focus during a difficult time.

Season 05, Episode 11 – “THE GROUND SHIFTS BENEATH US”
After a major accident at O’Hare, the E.D. is concerned one of their own is in mortal danger. Will’s proposal for a safe injection site goes to the board for consideration. Natalie and Goodwin become concerned for Gwen.

Season 05, Episode 12 – “LEAVE THE CHOICE TO SOLOMON”
The team deals with the aftermath of a school bus crash. Dr. Charles worries Dr. Halstead is putting his medical license in jeopardy. Maggie helps a friend in need.

Season 05, Episode 13 – “PAIN IS FOR LIVING”
Two brothers in critical condition are rushed into the hospital by their parents. Dr. Choi, April and Dr. Charles are left to tend to their care and to piece together what actually transpired. Dr. Manning becomes suspicious of a new mother entering the E.D. Dr. Halstead’s tireless activities at the safe injection site start to take a toll on his work.

Season 05, Episode 14 – “IT MAY NOT BE FOREVER”
Dr. Manning and Dr. Marcel disagree over an abusive husband. Dr. Halstead struggles with ethics and his decision to work at the safe injection site. Dr. Charles and Elsa reveal a misdiagnosis that may change a family’s life.

Season 05, Episode 15 – “I WILL DO NO HARM”
Dr. Charles and Dr. Manning treat a patient who is fully invested in pretending to be someone other than himself. Noah begins to doubt his abilities as a doctor. Dr. Marcel and Dr. Choi are faced with a tough ethical decision. Dr. Halstead puts his faith in an addict.

Season 05, Episode 16 – “WHO SHOULD BE THE JUDGE”
A convicted murderer’s escape hits close to home when several members of the team find themselves in danger. Dr. Charles and Dr. Halstead continue to clash over patient treatment plans. Dr. Choi and April discover the truth about a patient’s scam. Maggie finally receives some good news.

Season 05, Episode 17 – “THE GHOST OF THE PAST”
Marking the series milestone 100th episode, Dr. Manning and Dr. Charles assist in a complicated case helping a 4-year old who they quickly learn is no stranger to the ED. Dr. Marcel and Dr. Choi tend to a police officer with a mysterious gunshot wound to the abdomen. Relationships are put to the test as secrets are revealed.

Season 05, Episode 18 – “IN THE NAME OF LOVE”
Dr. Charles and Goodwin fear Dr. Halstead is repeating his past mistakes when a patient with early-onset Alzheimer’s is brought into the E.D. Maggie and Ben become concerned when one of Ben’s students is admitted. Dr. Manning and Dr. Marcel treat a terminally ill patient and disagree over the best course of action.

Season 05, Episode 19 – “JUST A RIVER IN EGYPT”
Dr. Charles evaluates a 15 year old who is brought into the E.D. after an apparent fall off an overpass. Will sides with Dr. Asher on a risky treatment plan. Tensions run high between Dr. Choi and Dr. Marcel.

Season 05, Episode 20 – “A NEEDLE IN THE HEART”
Dr. Crockett is visited by two New Orleans detectives who have questions about his past. Dr. Choi puts his life in danger to save a child. Dr. Charles gives fatherly advice to his young daughter.

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